📘 Lacture -5 Factors Affecting Drug Metabolism Including Stereochemical Aspects (Medicinal Pharmaceutical Chemistry – Semester IV)
📘 Factors Affecting Drug Metabolism Including Stereochemical Aspects (Medicinal Pharmaceutical Chemistry – Semester IV) 🌟 Introduction Have you ever wondered why the same drug behaves differently in different patients ? Or why one enantiomer of a drug is more active than the other ? The answer lies in drug metabolism and its influencing factors , including an important and often asked topic — stereochemical aspects of drug metabolism . This topic is high-yield for exams and very important for understanding real clinical practice . 🔬 What is Drug Metabolism? Drug metabolism is the biochemical modification of drugs by enzymes, mainly in the liver , to make them: ✔ More water-soluble ✔ Easier to excrete ✔ Pharmacologically less active (in most cases) 📌 Exam definition: Drug metabolism is the enzymatic conversion of lipophilic drugs into more polar metabolites. 🧠 Factors Affecting Drug Metabolism 1️⃣ Age 👶 Neonates & Infants: Immature liver enzymes ...