🚀 Medicinal & Pharmaceutical Chemistry – Lecture 3 Physicochemical Properties of Drugs & Their Role in Drug Action
Physicochemical Properties of Drugs & Their Role in Drug Action ⭐ Why This Topic Matters Before a drug shows any action in the body, it must reach the site , bind to the receptor, and stay stable . All this depends on… 👉 Physicochemical Properties This lecture will make these concepts super easy so you can score high in exams AND understand drug design better. 🔥 What You Will Learn in This Lecture ✔ What pKa tells about drug absorption ✔ Why LogP is the “passport” to cell membranes ✔ Why some drugs dissolve easily and some don’t ✔ How hydrogen bonding changes drug behaviour ✔ What makes a drug cross BBB ✔ What are isosteres and bioisosterism (exam favourite!) ✔ How stereochemistry can change a drug from medicine to poison 🧠 1. Ionization & pKa: The Real Reason Why Drugs Work pKa = the pH at which 50% drug is ionized and 50% unionized . Why is this important? Forms Properties Ionized form More soluble, less permeable Unionized form Less soluble, ...