lacture 5 Limit Test for Chloride | Pharmaceutical Inorganic Chemistry
Limit Test for Chloride | Pharmaceutical Inorganic Chemis try limit test for chloride Introduction The limit test is used to determine whether the amount of chloride impurity present in a pharmaceutical substance is within the prescribed limits. What is the Limit Test for Chloride? The Limit Test for Chloride is a semi-quantitative test used to detect and control chloride impurities in pharmaceutical substances. The amount of chloride present in the sample is compared with a standard solution containing a known amount of chloride. If the turbidity produced by the test solution is not greater than that of the standard solution, the sample passes the test. Principle Chloride ions react with silver nitrate (AgNO₃) in the presence of nitric acid to form a white precipitate of silver chloride (AgCl). Reaction: Ag⁺ + Cl⁻ → AgCl ↓ The turbidity produced due to the formation of silver chloride is compared with that of a standard chloride solution Requirements The following reagents are r...