π§ͺ Inorganic Chemistry Unit 1 Notes (B.Pharm) Lacture -1 Impurities in Pharmaceutical substances explained with examples
π§ͺ Inorganic Chemistry Unit 1 Notes (B.Pharm) π Introduction Inorganic chemistry is a fundamental subject in pharmaceutical sciences. It focuses on drug purity, detection of impurities, and maintaining quality standards. π§© What are Impurities? Impurities are unwanted substances present in pharmaceutical products that may affect their safety and efficacy. Types of Impurities: Organic impurities Inorganic impurities Residual solvents ⚠️ Sources of Impurities Impurities can originate from: Raw materials Manufacturing process Storage conditions Containers π¬ Limit Test Limit tests are semi-quantitative tests used to detect impurities within acceptable limits. Common Limit Tests: Chloride Sulphate Iron Arsenic Heavy metals π§ͺ Example: Limit Test for Chloride Principle: Chloride ions react with silver nitrate to form a white precipitate of silver chloride. Reaction: NaCl + AgNO₃ → AgCl ↓ Interpretation: The turbidity of the test solution is compared with a standard solution. Within l...