Drug of the Day: Atorvastatin

🌟 

📌 Drug Class: HMG-CoA Reductase Inhibitor (Statin)

📌 Used for: Cholesterol Control & Heart Disease Prevention

🔍 Introduction

Atorvastatin is one of the most commonly prescribed drugs for lowering high cholesterol levels.

It plays a vital role in preventing heart attacks, strokes, and other cardiovascular diseases, making it extremely important in both clinical practice and pharmacy education.

🧪 Chemical Information

Generic Name: Atorvastatin

Molecular Formula: C₃₃H₃₅FN₂O₅

Molecular Weight: 558.64 g/mol

Drug Category: Statins

⚙️ Mechanism of Action (MOA)

Atorvastatin works by inhibiting the enzyme HMG-CoA reductase in the liver.

This enzyme is responsible for cholesterol synthesis.

🔽 Effects:

Decreases LDL cholesterol

Decreases triglycerides

Increases HDL cholesterol

💊 Therapeutic Uses

✔ Hypercholesterolemia

✔ Mixed dyslipidemia

✔ Prevention of coronary artery disease

✔ Secondary prevention after heart attack

⚠️ Common Side Effects

Muscle pain (myalgia)

Headache

Nausea

Mild elevation of liver enzymes

❌ Contraindications

🚫 Active liver disease

🚫 Pregnancy and breastfeeding

🚫 Severe hepatic impairment

🧠 Exam-Oriented Point

Atorvastatin is a statin that inhibits HMG-CoA reductase, leading to reduced cholesterol synthesis in the liver.

✔ Ideal answer for B.Pharm / GPAT / Nursing exams

📚 Clinical Tip

💡 Unlike some statins, Atorvastatin can be taken at any time of the day, with or without food.

🧪 Student Practice MCQs

Q1. Atorvastatin belongs to which drug class?

A) ACE inhibitors

B) Beta blockers

C) Statins ✅

D) Calcium channel blockers

Q2. Which enzyme is inhibited by Atorvastatin?

A) Cyclooxygenase

B) Monoamine oxidase

C) HMG-CoA reductase ✅

D) CYP3A4

🔗 Related Posts (Internal Linking)

👉 Drug of the Day: Metformin

👉 Drug of the Day: Amlodipine

👉 Drug of the Day: Ciprofloxacin

(Helps SEO & increases page views 🚀)

💬 Student Engagement Section

📢 Question for Students:

Why are statins preferred for long-term prevention of cardiovascular diseases?

📝 Share your answer in the comments!