Pharma Easy Notes @Pharmacy

Youtube video link here- History and development of Medicinal chemistry   Emper2000BC Materia medica 250 vegitables drug and 120 mineral drug 1500BC Egyptian papyrus ebers 700 drugs originated from animal/plants/minerals Emperor Frederick II issued the Magna Carta pharmacy in 1240 Synthesis of urea 1828 started Organic medicinal chemistry  Enrlich’s  Side chain theory  chemotherapy Fischer’s lock and key theory Birth of Modern Med chem 1800 Medicinal chemistry received formal recognition in academic pharmcy in 1932 In 1910 -1946 Dale and Abiquist 1st proposed the receptor sub-types for cholinergic receptor  In 1936 - Sulphonamide In1940- Penicillin antibiotics In 1949 Chloramphenicol and Tetracycline In 1940 -1980 2nd Phase of Modern Medicinal Chemistry Introduction of all modern therapeutic classes. In 1945 -1965 ‘Golden era’ Many important therapeutic classes of drugs were invented. Examples 1949 - Corticosteroids 1950 - Antipsychotic  1955 - Antidepressants  1957 - Hypoglycemic 1959

introduction to Medicinal chemistry https://youtu.be/hkDUTveB-Ws?si=B9JrmOf86FXRdq9s In medicinal chemistry The chemist attempt to design and Synthesized a medicine or pharmaceutical agent which will benefit humanity. Such a compound known as Drug It involves : Synthesis Structure activity relationship (SAR) Receptor interactions- Absorption          Distribution          Metabolism         Excretion  According to IUPAC: Medicinal chemistry it concern  discovery, development, Identification , Interpretation Of mode of action of biological active compounds at the molecular level Medicinal chemistry covers three stages Discovery step-   Involving choice of therapeutic Target (receptor, enzyme and target group, cellular invivo model).Identification or discovery. Production of new active substances interacting with selected target. Such compounds called Lead compound     2. An optimization step - Which deals with improvement of lead compound.The optimization process takes primarily into