lacture -2. History and development of Medicinal Chemistry


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History and development of Medicinal chemistry 


  • Emper2000BC Materia medica 250 vegitables drug and 120 mineral drug

  • 1500BC Egyptian papyrus ebers 700 drugs originated from animal/plants/minerals

  • Emperor Frederick II issued the Magna Carta pharmacy in 1240

  • Synthesis of urea 1828 started Organic medicinal chemistry 

  • Enrlich’s 

  • Side chain theory 

  • chemotherapy

  • Fischer’s lock and key theory Birth of Modern Med chem 1800

  • Medicinal chemistry received formal recognition in academic pharmcy in 1932

  • In 1910 -1946 Dale and Abiquist 1st proposed the receptor sub-types for cholinergic receptor 

  • In 1936 - Sulphonamide

  • In1940- Penicillin antibiotics

  • In 1949 Chloramphenicol and Tetracycline

  • In 1940 -1980 2nd Phase of Modern Medicinal Chemistry Introduction of all modern therapeutic classes.

  • In 1945 -1965 ‘Golden era’ Many important therapeutic classes of drugs were invented.

Examples

  • 1949 - Corticosteroids

  • 1950 - Antipsychotic 

  • 1955 - Antidepressants 

  • 1957 - Hypoglycemic

  • 1959 - Contraceptives

  • 1960 - Benzodizepines

  • In 1960 The teratogenic effect ( birth of deformed children when mother consumed the drug during pregnancy) came to limelight after thalidomide (sedative).

  • In 1964 “Birth of QSAR” by Hansch.


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