Pharma Easy Notes @Pharmacy

💊 Drug of the Day – 4 : Amoxicillin 📅 Series: Drug of the Day (PharmaEasyNotes) 📖 Category: Pharmacology | Antibiotics 🔹 Introduction Amoxicillin is a broad-spectrum β-lactam antibiotic belonging to the penicillin group . It is one of the most commonly prescribed antibiotics worldwide due to its high efficacy, oral bioavailability, and safety profile . 🔹 Structure 🧪 Amoxicillin is a semi-synthetic derivative of ampicillin with an added hydroxyl group. 🔹 Mechanism of Action (MOA) Inhibits bacterial cell wall synthesis Binds to penicillin-binding proteins (PBPs) Prevents peptidoglycan cross-linking Leads to cell lysis and bacterial death 👉 It is bactericidal in action. 🔹 Pharmacokinetics Absorption: Well absorbed orally Distribution: Wide distribution, including respiratory tract, middle ear, urine Metabolism: Partial hepatic metabolism Excretion: Renal excretion (mainly unchanged drug) 🔹 Uses / Indications ✅ Respiratory tract infe...