💊 Drug of the Day – 5 : Ciprofloxacin
💊 Drug of the Day – 5 : Ciprofloxacin 📅 Series: Drug of the Day (PharmaEasyNotes) 📖 Category: Pharmacology | Antibiotics 🔹 Introduction Ciprofloxacin is a fluoroquinolone antibiotic widely used for treating Gram-negative bacterial infections . It is especially effective in urinary tract infections, gastrointestinal infections, and respiratory infections . 🔹 Structure 🔹 Mechanism of Action (MOA) Belongs to 2nd generation fluoroquinolones Contains a fluorine atom at C-6 that enhances antibacterial activity 🔹 Mechanism of Action (MOA) Inhibits DNA gyrase (Topoisomerase II) and Topoisomerase IV Prevents bacterial DNA replication & transcription Leads to bacterial cell death 👉 Bactericidal in action 🔹 Pharmacokinetics Absorption: Good oral bioavailability Distribution: Penetrates well into tissues and fluids Metabolism: Partially hepatic Excretion: Mainly via kidneys (renal excretion) 🔹 Uses / Indications ✅ Urinary tr...