Pharma Easy Notes @Pharmacy

  Introduction The receptor concept was formulated by John. N. Langley in 1907 ( Worked on the antagonism of atropine and Pilocarpine) Drugs that interact with receptor are most important in medicine and provide treatment for ailments such as ( 3PDHA) P ain P arkinson's disease P sychosis D epression H eart failure A sthma & Many other problems There are large numbers of different receptors in the body that interact with different chemical messengers For example - Acetylcholine - Cholinergic receptor Dopamine - Dopaminergic receptor γ -aminobutyric Acid - GABA receptor Epinephrine - Adrenergic receptor The various receptors show selectivity for one chemical messenger over another because they have a binding site of

Introduction What is Drug? The drug is a chemical molecule or medical agent used for ( D, P, Ts, Cd) D iagnosis P revention T reatment of symptoms C ure of Disease The desired pharmacological response of the drug can only be achieved if it is present at the site of action in appropriate concentration for a sufficiently long time. Content General Principle of drug action Introduction Absorption of drug Distribution of drug Protein binding Metabolism and Excretion This appropriate concentration is governed by the following factors- A&a